Natural products from microbes and men
Helge B. Bode,
Helge B. Bode, MPI für terrestrische Mikrobiologie, Marburg, Germany; Phillips Universität Marburg, Marburg, Germany; Goethe Universität Frankfurt, Frankfurt, Germany; SYNMIKRO, Marburg, Germany
Microbial natural products are a major source and inspiration for bioactive drugs in agriculture, animal health and medicine. However, we know only a small fraction of these microbial natural products and we are missing tools to broaden their chemical diversity beyond what we can currently find in nature.
In my talk, I will present methods from our lab to (i) activate and/or manipulate biosynthetic gene clusters from proteobacteria for the efficient production of desired natural products and to (ii) use the engineering of non-ribosomal peptide synthetases (NRPS) for the generation of new peptides and to understand biosynthesis pathways in molecular detail.
Prof. Dr. Helge B. Bode
Born 1973, German, married, 2 children
Max Planck Institute for Terrestrial Microbiology (MPI)
Department of Natural Products in Organismic Interactions
Karl-von-Frisch-Str. 10
D-35043 Marburg
Germany
Phone: +49 6421 178-501
Mailto: helge.bode@mpi-marburg.mpg.de
Prof. Dr. Helge B. Bode
Born 1973, German,
Max Planck Institute for Terrestrial Microbiology (MPI)
Department of Natural Products in Organismic Interactions
Karl-von-Frisch-Str. 10
D-35043 Marburg
Germany
Phone: +49 6421 178-501
Mailto: helge.bode@mpi-marburg.mpg.de
1997 Diploma in Chemistry, University of Göttingen (D)
2000 Dr. rer. nat., Organic Chemistry, University of Göttingen (D)
2001 Diploma in Biology, University of Göttingen (D)
2000-2001 Postdoc, Biomolecular Chemistry, University of Göttingen (D)
2001-2002 Postdoc, German Research Center for Biotechnology (D)
2002-2003 Postdoc, Department of Biochemistry, Stanford University (USA)
2004-2005 Juniorprofessor, Natural Product Biotechnology, Pharmaceutical Biotechnology, Saarland University (D)
2006-2010 Emmy Noether Fellow (DFG), Saarland University (D) and Goethe University Frankfurt (D)
2008-2017 Merck-endowed chair (W3) for Molecular Biotechnology, Goethe University Frankfurt (D)
2018-2022 Professor for Molecular Biotechnology, Goethe University Frankfurt (D)
Since 2020 Director and Head of the Department of Natural Products in Organismic Interactions at the MPI Marburg (D)
Since 2022 Professor for Chemical Biology, Department of Chemistry, Philipps-Universität Marburg (D)
Since 2022 Goethe Research Professor for Molecular Biotechnology, Goethe University Frankfurt (D)